In recent years, the significance of peptides in the field of pharmaceutical chemistry has become increasingly prominent. The two are intertwined, bringing new opportunities and breakthroughs for the development of the pharmaceutical industry.
In the medical field, peptides are an essential and important component. Many endogenous polypeptides are themselves biologically active substances with therapeutic effects, such as insulin, growth hormone, etc. They directly participate in the physiological regulation of the human body and provide a natural drug blueprint for the treatment of related diseases. Moreover, polypeptide drugs developed based on peptides combine the advantages of small molecule chemical drugs and protein drugs, with good targeting, low immunogenicity, good tissue permeability, easy synthesis and modification, high safety, and less accumulation in tissues. They have shown significant efficacy in the treatment of anti-tumor, antibacterial, chronic metabolic diseases, cardiovascular diseases, immune diseases, etc., and have become one of the hotspots in pharmaceutical research and development. For example, semaglutide, as an analogue of glucagon-like peptide-1 (GLP-1), extends the half-life through structural modification of the natural peptide and plays an important role in the treatment of diabetes.
Pharmaceutical chemistry provides a solid technical support for the research and application of peptides. On the one hand, advanced chemical synthesis technologies, such as solid-phase synthesis technology, have greatly improved the synthesis efficiency and purity of peptides, making it possible to produce high-quality peptide drugs on a large scale, reducing production costs and promoting the industrialization process of peptide drugs. On the other hand, separation, purification, analysis and other technologies in the chemical field can ensure the quality and stability of peptide drugs and meet the strict quality standards of drugs.
In the process of drug research and development, the role of pharmaceutical chemistry cannot be ignored. Researchers use chemical technologies to modify and transform the structure of peptides to improve their pharmacokinetic properties, enhance efficacy, reduce side effects, etc., so as to screen out drug candidates with more clinical application value. At the same time, pharmaceutical chemistry also provides support for the formulation research and development of peptide drugs. Through reasonable formulation design, the stability and bioavailability of peptide drugs are improved, such as the development of long-acting sustained-release formulations and targeted formulations.
From a market perspective, the combination of peptides and pharmaceutical chemistry has also generated huge economic benefits. With the continuous improvement of people’s health needs and the increase in awareness of peptide drugs, the global peptide drug market continues to grow. It is expected that by 2030, the scale of the Chinese polypeptide drug market will reach 2056.5 billion yuan, the scale of the polypeptide API market will reach 652.5 billion yuan, and the scale of the polypeptide CDMO market will reach 185.1 billion yuan, which brings a broad market space for pharmaceutical chemical enterprises.
Post time: Dec-11-2024