As life expectancy increases around the world, there is an increasing need to delay aging and stay healthy. In this ongoing quest, scientists around the world are unraveling the biology of aging and working to find effective measures to combat it. Among them, there is an enzyme involved in energy metabolism, namely nicotinamide adenine dinucleotide (NAD+), which continues to attract the attention of scientists.
NAD+ is a key metabolite and coenzyme for a variety of metabolic and cellular processes in the body, plays an important role in many physiological processes, and is essential for maintaining human health. With increasing age, the level of NAD+ will gradually decline, and this decline has been found to be related to a variety of human aging phenomena. Elucidating the role of NAD+ in human aging is expected to reveal a promising anti-aging strategy.
The supplement Exploring NAD+ : Combating Cellular Aging summarizes several research highlights that summarize important findings in this growing field of research.
NAD+ is also closely related to the deacetylase (sirtuin). The family of deacetylases (SIRT1 to SIRT7) are NAD+ dependent enzymes that play a key role in skin health and aging by consuming NAD+ to regulate chemical processes. In 2020, Shengqin Su’s team at the University of Wisconsin-Madison published a review in Photochemistry and Photobiology 3, The known roles of SIRT3, SIRT4 and SIRT5 in skin aging and disease were reviewed.
Researchers say sirtuin plays a key role in the skin’s ability to maintain balance under environmental stress and is involved in skin collagen synthesis, protection against UV rays and maintenance of the skin barrier. In the future, the researchers will further elucidate the relationship between these proteins and NAD+ levels.
Post time: Mar-27-2025